LEWA Clean Process Market
	Pharmaceutical, Biotech and Personal Care Food and Beverages
	Supercritical Fluid
	Supercritical CO2 Particle Generation Techniques Supercritical Fluid Applications

LEWA Clean Process Market

1. Pharmaceutical, Biotech and Personal Care:

   
   

• LEWA Process Technologies in high purity applications/systems:

• Chromatography (LPLC, HPLC, SCC), MF/UF filtration:



LEWA diaphragm pumps for liquid-process chromatography in the pharmaceutical industry.

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• High purity systems:



High purity system

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• Buffer Make-up/Proportional blending
• Homogenization:



• Supercritical extraction
• Spray-drying:



Spray-drying

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• Tablet extrusion package:



• Bird flu vaccine production
• Dilution system:

 



Dilution system

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• Fabric softener manufacturing:

  

  Fabric softener manufacturing

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• LEWA has following applications for a wide variety of fluids in biotechnology, pharmaceutical industry and personal care:


1. Buffer solutions         
2. Chromatography        
3. Nutrient solutions
4. Liposomes            
5. Supercritical fluid           
6. Acids, alkalis
7. Antifoaming agents         
8. Insulin                
9. Biochemicals
10. Coatings     
11. Oil/water emulsion         
12. Deodorants
13. Cosmetics           
14. Natural products

• LEWA products, systems for clean process market:


1. LEWA sanitary pump
2. LEWA hygienic pump
3. LEWA EcoFeed
4. LEWA EcoPrime
5. All pumps in Intellidrive technology available

2. Food and Beverages:

Process integrity and product safety is a basic prerequisite in food technology. Hygienic aspects and cleanability play a major role: the process must remain inherently closed, contamination of the process fluids must be prevented at any stage of the production. LEWA systems make this possible.

LEWA has following applications for a wide variety of fluids in food and beverages:

1. Edible oil          
2. Gelatin       
3. Milk and margarine products
4. Cereals and sweets  
5. Colour and flavor additives
6. Functional food and nutraceuticals
7. Brewery & soft drinks

Pumps and packages in food and beverages manufacturing

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Supercritical Fluid:

A supercritical fluid (SCF) is a substance whose temperature and pressure are simultaneously above its critical point. The importance of supercritical fluid is: (a) Liquids have good solubilizing property (b) Gases have good diffusivity and compressibility.

1. Supercritical CO2:
   
   LEWA has many experiences in supercritical CO2 (SCCO2) applications and CO2 has the following key properties:
   
   1. Low critical temperature (31.1 C)
   2. Moderate critical pressure of 73 bar
   3. Non-flammable
   4. Non-toxic
   5. Miscible with organic solvents
   6. Recoverable after processing
   7. Diffuses faster than conventional liquid solvents
   8. Generally Recognized As Safe (GRAS) status
   9. Approved by the FDA for use in food and pharmaceuticals
   10. Eco-friendy
   11. Inexpensive

   

LEWA diaphragm pump for liquid CO2 , with cooling device

(Click on the above image to access the information page).

2. Particle generation techniques:

1. Rapid expansion of supercritical solutions (RESS).
2. Supercritical Fluid Nucleation.
3. Anti solvent processes:
   1. Gas solvent recrystallization (GAS)
   2. Supercritical anti solvent (SAS) technique
   3. Aerosol solvent extraction system (ASES)
4. Solution Enhanced Dispersion by Supercritical Fluids (SEDS)
5. Impregnation or infusion of polymers with biosactive materials

3. Supercritical fluid application:

1. Supercritical Fluid Extraction (SFE):
   1. Caffeine from coffee bean, oil from nuts, Omega oils from fish.
   2. Extraction and separation of uranium waste, polychlorinated biphenyls (PCB) and methane.
   3. Extraction of heavy metals in ash.
2. Supercritical Fluid Chromatography (SFC) :
   1. Chiral Seperations.
   2. Low, middle and high Pressure liquid Chromatography (LPLC/MPLC/HPLC).
3. Micronization: Estradiol, Phenacetin
4. Antisolvent technique for drugs:
   1. Insulin
   2. Lysoyme
   3. Tripsin
   4. Hydrocortisone Acetate
5. Supercritical fluid cleaning:
   1. Precision cleaning of parts in the semiconductor and microelectronics industry
   2. Cleaning of critical medical components